Title: Design of Caspase Inhibitors as Potential Clinical Agents

Author(s): Tom O'Brien, Steven D. Linton

Series: Enzyme Inhibitors

Publisher: CRC

ISBN: 1420045407

Publication: 2008

Pages: 327

Description: Caspases represent one of the most specific protease families described to date. As caspase family members are involved in pro-inflammatory responses, inhibition of caspase activity represents a novel yet core approach to disease treatment. Design of Caspase Inhibitors as Potential Clinical Agents discusses the role of cysteine aspartyl proteases (caspases) in inducing cell death. It reviews recent efforts to develop small molecular inhibitors that are capable of modulating caspase activity. The text also examines the difficulties encountered in transitioning small molecular inhibitors from the lab to clinical use, and discusses how these challenges can best be overcome to allow continued progress.

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